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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDH2
All Species:
30.61
Human Site:
S18
Identified Species:
51.79
UniProt:
P40926
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40926
NP_005909.2
338
35503
S18
A
A
L
R
R
S
F
S
T
S
A
Q
N
N
A
Chimpanzee
Pan troglodytes
XP_001156205
338
35499
S18
A
A
L
R
R
S
F
S
T
S
A
Q
N
N
A
Rhesus Macaque
Macaca mulatta
XP_001114888
374
39932
A54
S
S
V
S
E
S
Q
A
L
L
V
V
N
N
A
Dog
Lupus familis
XP_849944
338
35431
S18
A
A
L
R
R
S
F
S
T
S
A
Q
N
N
A
Cat
Felis silvestris
Mouse
Mus musculus
P08249
338
35593
S18
A
A
L
R
R
S
F
S
T
S
A
Q
N
N
A
Rat
Rattus norvegicus
P04636
338
35665
S18
A
A
L
R
R
S
F
S
T
S
A
Q
N
N
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415765
351
36949
A31
A
V
L
C
R
G
L
A
T
S
A
Q
N
N
A
Frog
Xenopus laevis
NP_001085326
338
35691
S18
H
G
L
I
R
G
L
S
T
T
A
Q
A
N
A
Zebra Danio
Brachydanio rerio
NP_998296
337
35401
T18
S
L
V
R
S
L
S
T
S
S
Q
N
N
A
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650696
336
35299
S18
L
Q
G
V
R
T
F
S
V
G
Q
Q
N
N
Y
Honey Bee
Apis mellifera
XP_392478
338
35783
S21
Q
Q
G
A
K
R
L
S
T
S
A
K
C
N
A
Nematode Worm
Caenorhab. elegans
O02640
341
35101
V22
S
G
L
R
A
V
S
V
R
H
S
S
Q
A
P
Sea Urchin
Strong. purpuratus
XP_792004
337
35239
S20
A
Q
S
M
K
S
F
S
T
S
C
E
A
N
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SN86
403
42387
G76
T
S
D
K
K
P
Y
G
F
K
I
N
A
S
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
85.8
93.1
N.A.
94.9
94.3
N.A.
N.A.
84.3
84
84.6
N.A.
58.8
65
56.8
68.3
Protein Similarity:
100
100
88.5
97
N.A.
98.2
97.9
N.A.
N.A.
91.1
92
93.1
N.A.
76.3
80.7
72.7
83.1
P-Site Identity:
100
100
26.6
100
N.A.
100
100
N.A.
N.A.
66.6
53.3
20
N.A.
40
40
13.3
46.6
P-Site Similarity:
100
100
53.3
100
N.A.
100
100
N.A.
N.A.
73.3
60
46.6
N.A.
46.6
53.3
26.6
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
50.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
63.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
50
36
0
8
8
0
0
15
0
0
58
0
22
15
65
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
8
0
8
0
0
% C
% Asp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
50
0
8
0
0
0
0
0
0
% F
% Gly:
0
15
15
0
0
15
0
8
0
8
0
0
0
0
0
% G
% His:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
0
8
0
0
0
0
% I
% Lys:
0
0
0
8
22
0
0
0
0
8
0
8
0
0
8
% K
% Leu:
8
8
58
0
0
8
22
0
8
8
0
0
0
0
0
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
15
65
79
0
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% P
% Gln:
8
22
0
0
0
0
8
0
0
0
15
58
8
0
0
% Q
% Arg:
0
0
0
50
58
8
0
0
8
0
0
0
0
0
0
% R
% Ser:
22
15
8
8
8
50
15
65
8
65
8
8
0
8
8
% S
% Thr:
8
0
0
0
0
8
0
8
65
8
0
0
0
0
0
% T
% Val:
0
8
15
8
0
8
0
8
8
0
8
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
15
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _